EARLY-INFANTILE DEE (EIDEE)

	Mandatory	Alerts
Seizures	Tonic and/or myoclonic seizures
EEG	Burst suppression or multifocal discharges Diffuse slowing
Age at onset	Birth to 3 months (adjusted for prematurity)
Development at onset		Reported normal development
Neurological exam		Normal exam at onset
Early Comorbidities	Developmental impairment evident at or shortly after seizure onset
Course of illness	Abnormal development persists, and later includes intellectual impairment
Are MRI or ictal EEG required for diagnosis? An MRI is not required for diagnosis but is strongly recommended to exclude a structural cause An ictal EEG is not required in an infant with characteristic clinical features where the interictal EEG shows burst-suppression, multifocal discharges and diffuse slowing
Syndrome without laboratory confirmation: in resource-limited regions, this syndrome cannot be diagnosed without an interictal EEG

NOTE Alert criteria are absent in the vast majority of patients with the syndrome, but rarely can be seen. Their presence should result in caution in diagnosing the syndrome and consideration of other conditions