SELF-LIMITED FAMILIAL NEONATAL-INFANTILE EPILEPSY (SeLFNIE)

GENETICS

PATTERN OF INHERITANCE

Autosomal dominant inheritance with high penetrance.

KNOWN GENES

Pathogenic variants are found in either SCN2A or less commonly in KCNQ2.

FAMILY HISTORY OF SEIZURES/EPILEPSY

Different individuals in the family will have either neonatal or infantile onset focal seizures.