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SELF-LIMITED EPILEPSY WITH CENTROTEMPORAL SPIKES (SeLECTS)

Background

The background must be normal, with the presence of normal sleep architecture.

Interictal

High amplitude centrotemporal spike-, sharp- or sharp-waves that activate in drowsiness and sleep are mandatory. These may be unilateral or bilateral and are usually frequent. The centrotemporal spike/sharp has a typical triphasic morphology with a transverse dipole - maximum negativity in centrotemporal electrodes (C3/C4 and T3/T4) and maximum positivity frontally. Epileptiform abnormality may be seen in other areas (midline, parietal, frontal, occipital).

eeg
Example of centrotemporal sharp waves, bipolar montage.

eeg
Example of centrotemporal sharp waves, referential montage.

CAUTION If marked activation in sleep right arrow review for a history of language or cognitive regression (consider developmental and/or epileptic encephalopathy with spike-wave activation in sleep)

Activation

Epileptiform activity increases in drowsiness and sleep, when discharges often have a wider field and may become bilaterally synchronous. In 10-20% of children, centrotemporal discharges may be activated by sensory stimulation of the fingers or toes.

eeg
Example of EEG in the awake state.

eeg
Example of EEG in the same patient, showing activation in sleep.

Ictal

Seizures are infrequent, so it is rare to obtain an ictal recording and there are few published reports of these in the literature. Seizures may be accompanied by a brief decrease in amplitude of the background EEG, followed by diffuse sharp-wave discharges of increasing amplitude, predominantly in one centrotemporal region. In a focal to bilateral tonic-clonic seizure, the ictal discharges become bilaterally synchronous (as opposed to generalized).

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