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HYPOTHALAMIC HAMARTOMA

Background

The background EEG may be normal, and is often so initially. Focal slowing may also be seen (temporal > frontal > occipital areas). In the presence of epileptic spasms or generalized seizure types, the background may show widespread slowing or hypsarrhythmia.

Interictal

The interictal EEG is usually normal. Focal interictal epileptiform abnormality can be seen (in temporal > frontal > occipital areas).

Multi-focal independent spikes or generalized spike-wave (usually <3Hz) can be seen in those with generalized seizure types.

Hypsarrhythmia can be seen in those with epileptic spasms.

Activation

EEG abnormality is enhanced by sleep deprivation, in drowsiness and in sleep. Obtaining a sleep EEG is important in infants at risk of epileptic spasms, as the awake EEG may be normal, and abnormality may only be present in sleep.

Ictal

Hypothalamic hamartomas are not accessible by scalp EEG, and ictal EEG may be normal or may show only subtle attenuation or rhythmic slowing.

If epileptic spasms or generalized seizures are present, the ictal EEG associated with these seizure types may be seen.

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