CEREBRAL ANGIOMA

GENETICS

PATTERN OF INHERITANCE

• 80% - without family history, either occurring by chance, or due to a de novo acquired somatic gene abnormality.
• 20% - familial inheritance, with autosomal dominant inheritance (multiple angiomas are more common in familial cases).

KNOWN GENES

CCM1, CCM2 and CCM3.

FAMILY HISTORY

May be present (see above).