FAMILIAL FOCAL EPILEPSY WITH VARIABLE FOCI (FFEVF)

	Mandatory	Alerts	Exclusionary
Seizures	Focal seizures		Generalized seizures
EEG		Generalized epileptiform abnormality
Age at onset		Neonatal onset
Development at onset			Moderate or greater intellectual impairment
Neurological exam		Abnormal exam
Imaging	Normal or focal cortical dysplasia
Other	Family history of individuals with focal seizures arising from different cortical regions in different family members		Family history of focal seizures exclusively seen <20 months of age
Are MRI or ictal EEG required for diagnosis? An MRI is required for diagnosis to exclude other causes An ictal EEG is not required for diagnosis
Syndrome without laboratory confirmation: in resource-limited regions, this syndrome can be diagnosed without EEG in a patient if other mandatory and exclusionary criteria are met. However, an MRI or CT is required to exclude other structural causes

NOTE Alert criteria are absent in the vast majority of patients with the syndrome, but rarely can be seen. Their presence should result in caution in diagnosing the syndrome and consideration of other conditions